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View all →The Journal Bearing Analysis Suite
ARMY RESEARCH LABORATORY
Background The Journal Bearing Analysis Suite is the first transient journal bearing code to implement the Jacobsson-Floberg-Olsson (JFO) boundary conditions. It uses a mass conserving algorithm devised by Professor Emeritus Harold Elrod, Columbia University, and was written by David E. Brewe of the U.S. Army at the NASA Lewis Research Center in 1983. Since then, new features and improvements have been built into the code by several contributors supported through Army and NASA funding via co-operative agreements with the University of Toledo (Prof. Ted Keith, Jr. and Dr. D. Vijayaraghavan), National Research Council Programs (Dr. D. Vijayaraghavan). All this was conducted with the close consultation of Prof. H.G. Elrod and project management of D. E. Brewe. This version is written to perform a thermo-hydrodynamic analysis of fluid film Journal bearings using collocation across the film thickness at Lobatto points and using Legendre polynomials. The Technology Planetary gear systems are an efficient means of achieving high reduction ratios with minimum space and weight. They are used in helicopter, aerospace, automobile, and many industrial applications. High-speed planetary gear systems will have significant dynamic loading and high heat generation. Hence, they need jet lubrication and associated cooling systems. For units operating in critical applications that necessitate high reliability and long life, that have very large torque loading, and that have downtime costs that are significantly greater than the initial cost, hydrodynamic journal bearings are a must. Computational and analytical tools are needed for sufficiently accurate modeling to facilitate optimal design of these systems. Sufficient physics is needed in the model to facilitate parametric studies of design conditions that enable optimal designs.
Portable Biological Agent Detection The “PCR Rotary Thermalcycler Unit”
FirstLink
An established method for rapidly identifying a genetic fingerprint (the DNA) of biological materials in even trace samples is Polymerase Chain Reaction, or PCR. Yet, application of PCR in the field has been challenged by the cost and difficulty of currently transportable PCR equipment. The PCR Rotary Thermalcycler Unit is designed to be a simple-to-use, lightweight, portable device for rapidly detecting and identifying the presence of specific biological species while in the field. Its unique heating concept and design configuration is intended to enable convenient and affordable PCR for a wide range of field applications such as: Detecting diseases and agricultural pests Identifying dangerous biological agents Testing food and water for contamination Tracking geographically a species or biological agent Design Benefits: Portable and easy to operate On-the-scene analysis in 5-20 minutes Expandable for higher sample counts Self-contained platform (integral batteries and detectors) with intuitive display The U.S. Army Center for Health Promotion and Preventive Medicine seeks licensees to commercialize a PCR Rotary Thermalcycler, reducing the design to practice. Further development is possible under a Cooperative Research and Development Agreement (CRADA) for prototype development, testing, & adaptation of commercially available reagents. Additional information is available through FirstLink.
Immunoliposome Polymerase Chain Reaction (ILPCR) Assay
TechLink
A simple-to-make diagnostic immunoassay capable of sub-femtomolar sensitivity that is very robust against matrix contaminations. Background and Technology: The US Army has developed an ultrasensitive immunoassay capable of sub-femtomolar (10-15) limit of detection. ILPCR technology overcomes the limitations of traditional immuno-PCR by encapsulating the signal amplification DNA/reporter inside a liposome, and incorporating a receptor (e.g. biotin or gangliosides) as the detection reagent into the bilayer of the liposome. After immobilization of the target analyte by the specific capture molecule and co-binding of the detection reagent, the liposomes are ruptured to release the reporters, which are quantified by real-time PCR. Preparation of the ILPCR reagent is simple. Unlike traditional immuno-PCR, synthesis of an antibody/DNA conjugate is not needed. By encapsulating the reporter inside the liposome, the reporter is protected by the liposome from degradation by impurities, which substantially reduces the possibility of false-negative results, and enables the use of DNase I to all but eliminate DNA contamination and false-positives. ILPCR’s improved sensitivity is due in part to the high number of reporters per binding event and the low nonspecific binding of the reagents. The assay has shown 5 orders of magnitude in dynamic range. Benefits:Ultrasensitive: Demonstrated sub-attomolar (10-18) and sub-femtomolar (10-15) detection threshold capabilities under ideal and “real-world” conditions respectivelyBroad Dynamic Range: Five Orders of Magnitude Accurate: Protection of the reporter inside the liposome greatly reduces false-negatives; eliminates DNA contamination, hence substantially reduces false-positives Versatile: Reduced to practice in biotoxins (botulinum and cholera), oncology biomakers (CEA), and viral HIV detection systems; applicable to a multitude of other analytes of commercial interest Simple: Reagents are easy to manufacture, inexpensive, and have a long shelf-life Status and Opportunity: Available for license and commercialization:One issued US patent (7,582,430), one published US patent (2009/0176250), and various pending foreign filings (WO2005/067583) Peer-reviewed journal articles available; additional information under non-disclosure agreement Potential for R&D; collaboration with inventors Dr. Tim O'Leary & Dr. Jeff Mason
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